Use of TiPED* to detect endocrine disrupting activity of six known EDCs: BPA, Atrazine, Perfluorinated Compunds, Phthalates, Organotins and Perchlorate
|
|
BPA |
Atrazine |
Perfluorinated compounds |
Phthalates |
Organotins |
Perchlorate |
|
| Tier/Assay Type |
Specific Assay |
||||||
| Computer-Based | |||||||
| Chemical reactivity | |||||||
| Physio-chemical properties |
[151] |
||||||
| Docking modeling |
[152] |
[154] |
|||||
| QSAR |
[155] |
[156] |
|||||
| Targeted Cell Assays | |||||||
| Tox21 qHTS |
[157] |
[157] |
[157] |
||||
| Cell Processes Assays |
|||||||
| MCF7 cell prolifera-tion assay |
[158] |
[159] |
[160] |
||||
| Prostate cancer cell prolifera-tion assay, PSA assay |
[161] |
[162] |
|||||
| 3T3-L1 adipogen-esis assay |
[163] |
[163] |
[89] |
||||
| GH3 T-screen assay |
[164] |
[165] |
|||||
| Fish/Amphibia | |||||||
| Zebrafish rapid develop-mental toxicity HTS |
[109] |
[40] |
|||||
| Aquatic EDC reporter assays |
[43] (TH) |
||||||
| Medaka and fathead minnow reproduc-tive assays |
[168] |
[169] |
[170] |
[171] |
[172] |
||
| Xenopus metamorphosis assay |
[173] |
[174] |
[175] |
||||
| Xenopus sexual dimorph-ism assays |
[176] |
[177] |
[178] |
[179] |
|||
| Frog metamor-phosis assay |
[173] |
[174] |
[175] |
||||
| H. argus color change assay | |||||||
| Xenopus corticoid assay |
[51] |
||||||
| Mammalian | |||||||
| Asthma |
[180] |
||||||
| Brain sexual dimorph-ism assay |
[129] |
[181] |
[182] |
||||
| Mammary carcino-genesis assay |
[138] |
[183] |
|||||
| Mammary gland morpholo-gy assay |
[64] |
[184] |
[187] |
||||
| Maternal behavior assay |
[139] |
[188] |
|||||
| Obesity / Metabolic syndrome assays |
[191] |
[192] |
[89] |
||||
| Prostate carcinogenesis assay |
[193] |
||||||
| Sexual dimorph-ism behavior assays |
[129] |
||||||
| Tissue gene expres-sion assay |
[194] |
[195] |
[196] |
[197] |
[198] |
[199] |
*Based on a search of the peer-reviewed scientific literature.